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National Repository of Grey Literature 1 records found  Search took 0.01 seconds. 
Non-shivering thermogenesis - UCP1 and other alternative mechanisms
 Kružíková, Nikola ; Zouhar, Petr (advisor) ; Tauchmannová, Kateřina (referee)
Adaptive thermogenesis is a natural mechanism by which endothermic organisms increase their basal metabolic rate to maintain stable body temperature. During acute exposure to subthermoneutral temperatures, the first reaction of organism is shivering which is gradually replaced by nonshivering thermogenesis. Nonshivering thermogenesis in mammals is associated with a UCP1 protein located in the inner mitochondrial membrane in adipose cells. In active mode, UCP1 uncouples respiratory chain from ATP synthesis and by that significantly increases metabolic rate. Apart from UCP1, some alternative mechanisms of nonshivering thermogenesis were suggested - namely: sarcolipin uncoupling ATP hydrolysis from pumping calcium ions through SERCA pump in skeletal muscle, phosphocreatine hydrolysis in adipose tissue or futile cycling of triacylglycerols and fatty acids reesterification. However, to date, there is rather indirect and not generally accepted evidence that these mechanisms contribute significantly to adaptive nonshivering thermogenesis. Better understanding of the nonshivering thermogenesis processes would be of great clinical importance as it could allow identification of potential targets for pharmacological manipulation of energy expenditure and thus provide novel methods for reducing obesity and...
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